Strategies for controlled delivery of biologics for cartilage repair
نویسندگان
چکیده
منابع مشابه
Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair
Delivery of bioactive factors is a very valuable strategy for articular cartilage repair. Nevertheless, the direct supply of such biomolecules is limited by several factors including rapid degradation, the need for supraphysiological doses, the occurrence of immune and inflammatory responses, and the possibility of dissemination to nontarget sites that may impair their therapeutic action and ra...
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Articular cartilage is a unique tissue owing to its ability to withstand repetitive compressive stress throughout an individual's lifetime. However, its major limitation is the inability to heal even the most minor injuries. There still remains an inherent lack of strategies that stimulate hyaline-like articular cartilage growth with appropriate functional properties. Recent scientific advances...
متن کاملCurrent strategies for articular cartilage repair.
Defects of articular cartilage that do not penetrate to the subchondral bone fail to heal spontaneously. Defects that penetrate to the subchondral bone elicit an intrinsic repair response that yields a fibrocartilaginous repair tissue which is a poor substitute for hyaline articular cartilage. Many arthroscopic repair strategies employed utilise this intrinsic repair response to induce the form...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2015
ISSN: 0169-409X
DOI: 10.1016/j.addr.2014.06.006